Chemical Properties
white to light yellow crystal powder
Uses
4,7-Dichloroquinoline is used as a drug chloroquine phosphate intermediate. It was used in the synthesis of piperaquine. and as starting reagent in the synthesis of {3-amino-5-[(7-chloro-4-quinolyl)amino]phenyl}methanol.
Uses
4,7-Dichloroquinoline is used in the synthesis of hybrid aminoquinoline-triazine derivatives that show anti-microbial activity. In addition, it is used in the synthesis of novel oxazolidinones as anti
-microbial agents showing efficacy against common bacterial strains. Chloroquinoline impurity.
General Description
Chloroquine Related Compound A is an impurity of chloroquine, which is a 9-aminoquinoline drug that effectively inhibits viral infections in humans.
Flammability and Explosibility
Not classified
Synthesis
4,7-Dichloroquinoline is obtained by chlorination of 7-chloro-4-hydroxyquinoline.
Purification Methods
Crystallise the dichloroquinoline from MeOH or 95% EtOH. [Beilstein 20/7 V 316.]
