BAX Antibody

Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

Bax is a key component for cellular induced apoptosis through mitochondrial stress. Upon apoptotic stimulation, Bax forms oligomers and translocates from the cytosol to the mitochondrial membrane. Through interactions with pore proteins on the mitochondrial membrane, Bax increases the membrane's permeability, which leads to the release of cytochrome c from mitochondria, activation of caspase-9, and initiation of the caspase activation pathway for apoptosis.

References

[1] Wei, M.C. et al. (2001) Science 292, 727-30.
[2] Jürgensmeier, J.M. et al. (1998) Proc Natl Acad Sci U S A 95, 4997-5002.
[3] Narita, M. et al. (1998) Proc Natl Acad Sci U S A 95, 14681-6.
[4] Marzo, I. et al. (1998) Science 281, 2027-31.