CBP30, HUMAN

Uses

Galectin-3 human has been used:

• to test its interaction with N-acetyl lactosamine coated onto quantum dots
• to optimize Gal3-induced hemagglutination measurements in non-agglutinated or agglutinated chicken red blood cells (RBCs)
• in Gal-3 binding assay of serum samples from multiple sclerosis patients

General Description

Galectin-3 protein comprises a N-terminal flexible domain and a C-terminal carbohydrate-recognition domain (CRD). It is mapped to human chromosome 14q22.3. Galectin-3 is expressed in sensory neurons, immune endothelial?and epithelial cells.

Biochem/physiol Actions

Galectin-3 has been associated with the inhibition of apoptosis and the progression of cancer, as well as being a mediator of inflammation. Studies have found a positive correlation between the expression of galectin-3 and tumorigenicity and metastasis in colon, liver, and thyroid cancer.