Definition
ChEBI: 2,2',5,5'-Tetrachlorobenzidine is a member of biphenyls and a dichlorobenzene.
Production Methods
2,2' ,5,5' -Tetrachlorobenzidine is made by the reduction of 2,5-dichloronitrobenzene with zinc dust and sodium hydroxide solution. The subsequent rearrangement is carried out using sulfuric acid or hydrochloric acid. The dihydrochloride melts at 230 ℃. Tetrachlorobenzidine is marketed as the free base and is used to produce yellow pigments.
Biological Activity
Pyruvate kinase (PK) catalyzes the dephosphorylation of phosphoenolpyruvate(PEP) into pyruvate. It is also involved in glycolysis by releasing ATP.Allosteric effects and intracellular signal transduction regulate the enzymaticactivity of PKM1. PKM1 is involved in several biological processes such asmetabolic reprogramming, and innate and acquired immune response. Itparticipates in protein interactions, protein synthesis, glycolysis, andintranuclear signal transduction.
Safety Profile
Suspected carcinogen with experimental carcinogenic and tumorigenic data. When heated to decomposition it emits very toxic fumes of NO, and Cl-.
