Description
TCID (30675-13-9) inhibits ubiquitin C-terminal hydrolase L3 (UCH-L3). IC50=0.6 μM, 125-fold selective over UCH-L1, IC50=75 μM. Cell permeable.
References
[1] KERRY ROUTENBERG LOVE. Mechanisms, biology and inhibitors of deubiquitinating enzymes[J]. Nature chemical biology, 2007, 3 11: 697-705. DOI:
10.1038/nchembio.2007.43[2] NAMDORI R. MTANGO. Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation[J]. Journal of Cellular Physiology, 2011, 227 5: 2022-2029. DOI:
10.1002/jcp.22931