Description
Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of
Jacaranda plants. Structurally, it is an 18-carbon ω-6 triene isomer of γ-linolenic acid . Jacaric acid induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI
50 = 1-5 μM). It increases the production of reactive oxygen species, and cytotoxicity is abolished by the antioxidant α-tocopherol, suggesting that apoptosis results from oxidative stress. Jacaric acid is metabolized
in vivo to conjugated linoleic acid (Item No.
90140), which is also cytotoxic to cancer cells. Jacaric acid inhibits cyclooxygenase-1
in vitro (K
i = 1.7 μM) and, with long term feeding, decreases stearoyl-CoA desaturase expression and activity in mice.
Uses
8(Z),10(E),12(Z)-Octadecatrienoic Acid, is a conjugated Linoleic Acid, a compound that has reported to exhibit anticarcinogenic activity. Also a potent antioxidant.
