Uses
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project
(www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these
protocols and other useful information about Prestige Antibodies and the HPA, visit .
General Description
BRPF1 (bromodomain and plant homeodomain finger containing, 1) protein contains plant homeodomain (PHD) fingers, a bromodomain that recognizes acetylated histones, and a proline-tryptophan-tryptophan-proline (PWWP) domain.
Biochem/physiol Actions
BRPF1 (bromodomain and plant homeodomain finger containing, 1) gene encodes a component of the monocytic leukemic zinc finger (MOZ) histone acetyltransferase (HAT), a quaternary complex that acetylates histones. This component activates MOZ HAT by linking the MOZ catalytic subunit to the ING5 (inhibitor of growth 5) and hEaf6 subunits and promotes acetylation of histones. It also recruits Moz to active chromatin during mitosis. The MOZ HAT complex also functions in proper patterning for skeletal development. The PWWP domain of this protein associates with H3K36me3 (Trimethylation of Lys36 in histone H3) that mediates the elongation phase of transcription and functions as an epigenetic regulator of cell growth and differentiation. The effector domains of human BRPF1 are involved in gene transcription, chromatin binding and remodeling.
