Description
Cytosolic phospholipase A2α (cPLA
2α) specifically catalyzes the hydrolysis of arachidonic acid from the
sn-
2-
ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process. CAY10650 is a highly potent (IC
50 = 12 nM) cPLA
2α inhibitor. It demonstrates strong anti-
inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis. The phase I metabolite of this compound, CAY10641 , is also available.
