17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester

Description

Prostaglandin F_2α (PGF_2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity.^1,2,3 17-trifluoromethylphenyl trinor PGF_2α is an analog of PGF_2α that shares the meta-trifluoromethyl group of travoprost with the 17-phenyl trinor modification of latanoprost. It is anticipated to be a potent and selective agonist of the FP receptor, with potential applications in glaucoma and luteolysis. 17-trifluoromethylphenyl trinor PGF_2α methyl ester is a lipophilic analog of 17-trifluoromethylphenyl trinor PGF_2α. Methyl esters of PGs serve as prodrugs, as they are efficiently hydrolyzed in certain tissues to generate the bioactive free acid.

References

1. Samuelsson, B., Goldyne, M., Granstr?m, E., et al. Prostaglandins and thromboxanes Annu. Rev. Biochem. 47,997-1029(1978).
2. Speroff, L., and Ramwell, P.W. Prostaglandins in reproductive physiology Am. J. Obstet. Gynecol. 107(7),1111-1130(1970).
3. Crankshaw, D.J., and Gaspar, V. Pharmacological characterization in vitro of prostanoid receptors in the myometrium of nonpregnant ewes J. Reprod. Fertil. 103(1),55-61(1995).