Uses
thiazolidin e thione pharmaceutical intermediate
Uses
3-Propionylthiazolidine-2-thione is used to synthesis of β-hydroxy-α-methyl carboxylic esters, amides, and aldehydes, propionate equivalent for the diastereo- and enantioselective aldol reactions.
Preparation
Preparative Methods of 3-Propionylthiazolidine-2-thione: from propionyl chloride and 1,3-Thiazolidine-2-thione in the presence of Triethylamine, or from
Propionic Acid and thiazolidine-2-thione in the presence of triethylamine and 2-Chloro-1-methylpyridinium Iodide.
[1]
References
1. (a) Izawa, T.; Mukaiyama, T. CL 1977, 1443. (b) Izawa, T.; Mukaiyama, T. BCJ 1979, 52, 555
