Chemical Properties
light yellow liquid
Uses
N,N'-Dibenzylethylenediamine is an intermediate of cephalosporin and penicillin.
Definition
ChEBI: Benzathine is a diamine. It is a conjugate base of a benzathine(1+).
Synthesis Reference(s)
The Journal of Organic Chemistry, 55, p. 3209, 1990
DOI: 10.1021/jo00297a042
Safety Profile
Poison by ingestion,intraperitoneal, and parenteral routes. When heated todecomposition it emits toxic vapors of NOx.
Purification Methods
Dissolve DBED in acid, extract with toluene, basify, extract it with Et2O, dry over solid KOH, evaporate and fractionate it in vacuo. The diacetate crystallises from H2O by addition of EtOH and has m 111o (solubility in H2O is ~25%). The dihydrochloride has m 306-308o (from H2O) and the dipicrate has m 212o(dec) (from H2O). [Frost et al., J Am Chem Soc 71 3842 1949, Beilstein 12 H 1067, 12 III 2304.]
