Description
2-Fluoro-4-iodo benzonitrile is a building block. It has been used in the synthesis of
L. infantum trypanothione reductase (
Li-TryR) dimerization and oxidoreductase activity inhibitors. 2-Fluoro-4-iodo benzonitrile has also been used in the synthesis of transient receptor potential ankyrin 1 (TRPA1) antagonists.
Chemical Properties
Light yellow crystalline
Uses
Used as pharmaceutical intermediates.
References
[1] ALEJANDRO REVUELTO. Pyrrolopyrimidine vs Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase[J]. ACS Infectious Diseases, 2019, 5 6: 873-891. DOI:
10.1021/acsinfecdis.8b00355[2] KARL S.A. VALLIN . N-1-Alkyl-2-oxo-2-aryl amides as novel antagonists of the TRPA1 receptor[J]. Bioorganic & Medicinal Chemistry Letters, 2012, 22 17: Pages 5485-5492. DOI:
10.1016/j.bmcl.2012.07.032
