Uses
Monoclonal Anti-Human Kappa Light Chain (Bound and Free) antibody produced in mouse has been used for:
- immunodetection
- in western blot analysis
- in intracellular kappa light chain staining for flow cytometric analysis
Uses
Anti-Human Kappa Light Chain (Bound and Free) antibody produced in goat has been used in western blotting.
General Description
Anti-Human κ Light Chain (bound and free) antibody is obtained from goat antiserum. Immunospecific purification removes all goat serum proteins and immunoglobulins that do not bind to the κ light chain (bound and free). The antibody preparation is specific for κ light chains when tested against bound and free light chains. The product shows no reaction with bound or free λ light chains.
Biological Activity
Immunoglobulin K constant (IGKC) is a human gene th at encodes the constant domain of K-type light chains for antibodies. It is found on chromosome 2 in humans. IGKC acts as a strong prognostic marker in several human solid tumors, including breast cancer. Its expression may have a role for humoral immunity in breast cancer progression. IGKC is also found to be expressed in non-small lung cancer (NSCLC) and may act as a prognostic marker in NSCLC, supporting emerging treatment concepts th at exploit the humoral immune response. Its has an independent protective impact on disease-free survival (DFS) and breast cancer-specific overall survival in node-negative breast cancer. IGKC acts as a novel diagnostic marker for risk stratification in human cancer and may help to exploit the humoral immune response for anticancer therapy.
