Description
Trimethoprim-d
3 is intended for use as an internal standard for the quantification of trimethoprim by GC- or LC-MS. Trimethoprim is a synthetic antibiotic that inhibits dihydrofolate reductase (DHFR), which is necessary for the synthesis of purines, amino acids, and thymidylic acid. Trimethoprim shows prominent selectivity for bacterial DHFR over mammalian DHFR (IC
50s = 5 and 30,000 nM, respectively). Formulations containing trimethoprim, commonly used in combination with sulfamethoxazole to minimize acquired resistance, have been used in the treatment of urinary tract infections.
Chemical Properties
Off-White to Pale Yellow Solid
Uses
Deuterated Trimethoprim, an antibacterial
Uses
Trimethoprim-d3 (Major) is an antibacterial.
References
[1] THANH LAM. Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolines[J]. Journal of Medicinal Chemistry, 2014, 57 3: 651-668. DOI:
10.1021/jm401204g[2] BARRY I. SCHWEITZER Joseph R B Adam P Dicker. Dihydrofolate reductase as a therapeutic target[J]. FASEB Journal, 1990, 4 8: 2441-2452. DOI:
10.1096/fasebj.4.8.2185970
