Uridine-5'-O-triphosphoro-γ-1-(5-sulfonic acid)naphthylamidate (sodium salt)

Description

Uridine-5'-O-triphosphoro-γ-1-(5-sulfonic acid)naphthylamidate (UTP-γ-AmNS) is a fluorescent derivative of the nucleotide and dual purinergic P2Y2 and P2Y4 receptor agonist UTP (Item No. 9003530).1 It has been used in high-throughput screening (HTS) assays for inhibitors of bacterial RNA polymerase activity. Upon incorporation of UMP in RNA, γ-AmNS-PPi is released, which has an emission at 465 nm upon excitation at 360 nm and a higher fluorescence intensity than UTP-γ-AmNS.WARNING This product is not for human or veterinary use.

References

[1] JYOTHI BHAT . High-Throughput Screening of RNA Polymerase Inhibitors Using a Fluorescent UTP Analog[J]. SLAS Discovery, 2006, 11 8: Pages 968-976. DOI: 10.1177/1087057106291978