Description
Aluminum phthalocyanine disulfonate sodium, also known as AlPcS2 disodium or AlS2Pc or AlPcS(2a), is a potent photosensitizer, and is potentially useful in cancer sonodynamic therapy and cancer photodynamic therapy. Aluminum phthalocyanine disulfonate is a mixture of regional isomers, in which sulfonate group can be in 3- or 4- position in phenyl ring. Aluminum phthalocyanine disulfonate is also a Coloring Agent; Dermatologic Agent; Fluorescent Dye; Indicators and Reagent; Luminescent Agent; Photosensitizing Agent; Radiation-Sensitizing Agent.
in vitro
As seen in the diagrams, cells in control group 1 that comprised of cells neither treated with AlPcSmix (sulfonated aluminum phthalocyanine mix) nor exposed to light appeared structurally unaltered and retained their characteristic morphology after 24 hours of incubation. The cells appeared healthy and uninjured and actively proliferated to confluence in 24 hours. PDT treated cells on the other hand (AlPcSmix+ irradiation) showed visible structural alteration with increasing level of damage proportional to the increase in PDT doses. Although there was significant cell damage in both cell populations, the side population incurred less damage than the total cell population at similar dose concentrations. There was however observable cell morphology alterations showing cell shrinkage, blebbing and detachment from the plate surface._x000D_
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Reference: Oncotarget. 2019 Jul 9; 10(43): 4380–4396. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633885/
