Uses
Anti-RIPK1 antibody produced in rabbit has been used in immunoblotting and immunohistochemistry.
Uses
Anti-RIPK1 antibody produced in rabbit has been used in:
- western blotting
- immunocytochemistry
- immunofluorescence
General Description
Receptor interacting serine/threonine kinase 1 (RIPK1) gene is located at 6p25.2 on the human chromosome. It belongs to the RIPK family. RIPK1 is a necroptosis regulatory protein. It is made up of N-terminal kinase domain, a RIP homotypic interaction motif and its C-terminal contains the death domain.
Biochem/physiol Actions
Receptor interacting serine/threonine kinase 1 (RIPK1) is involved in inflammatory signaling and prosurvival. It is also involved in regulating the caspase-8-mediatedapoptosis. RIPK1 plays a role in activating nuclear factor kappa-light-chain-enhancer of activated B cells(NF-κB)andmitogen-activated protein (MAP) kinases. Mutations in this gene is associated with impaired innate and adaptive immunity. It also leads to very early onset inflammatory bowel diseases (VEO-IBDs).
