Uses
Altenusin is an antifungal penicillide and strong pp60c-Src inhibitor.
Definition
ChEBI: Altenusin is a carboxybiphenyl that is [biphenyl]-2-carboxylic acid which is substituted by a hydroxy group at positions 3, 4' and 5', methoxy group at position 5 and a methyl group at position 2'. It is a a metabolite isolated from Alternaria and several other fungal species. It has a role as an antifungal agent and a fungal metabolite. It is a polyphenol, a carboxybiphenyl, an aromatic ether, a member of hydroxybiphenyls and a member of catechols.
Biological Activity
Altenusin, a non-steroidal fungal metabolite, is a potent and selective agonist of Farnesoid X receptor (FXR) th at protects mice from high-f at diet induced obesity. Also it decreases blood glucose level, serum insulin level, and reduces lipid droplets accumulation. Altenusin inhibits trypanothione reductase from Trypanosoma cruzi.
