Uses
Velnacrine (HP 029 free base) is an inhibitor for acetylcholinesterase (AChE), with an IC50 of 3.27 μM. Velnacrine reverses the Scopolamine (HY-N0296)-induced amnesia in rat models, and exhibits acute toxicity with LD50 of 65 mg/kg[1].
Definition
ChEBI: 9-amino-1,2,3,4-tetrahydroacridin-1-ol is a member of acridines.
IC 50
AChE: 3.27 μM (IC
50)
References
[1] Tabarrini O, et al., Velnacrine thiaanalogues as potential agents for treating Alzheimer's disease. Bioorg Med Chem. 2001 Nov;9(11):2921-8. DOI:
10.1016/s0968-0896(01)00171-7