Description
Acyclovir-d
4 is intended for use as an internal standard for the quantification of acyclovir by GC- or LC-MS. Acyclovir is a guanosine analog that has antiviral activity
in vitro against the herpes simplex viruses, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and human herpes virus 6 (ID
50s = 0.1-63.1 μM). It diffuses freely into cells and is selectively converted into acyclo-guanosine monophosphate by a virus-specific thymidine kinase. During DNA replication, the phosphorylated form of acyclovir is preferentially incorporated into viral DNA, resulting in premature chain termination and inhibition of further DNA polymerase activity. Acyclovir (5 mg/kg) reduces viral titers in mice infected with the herpes simplex virus-1 (HSV-1) strain SC16.
Chemical Properties
Colourless Powder
Uses
Acyclovir-d4 can be intended for use as an internal standard for the quantification of Acyclovir by GC- or LC-mass spectrometry.
Uses
Acyclovir-d4can be ued as orally active acyclic labelled nucleoside with inhibitory activity towards several herpes viruses.
References
[1] BALFOUR H H. Management of cytomegalovirus disease with antiviral drugs.[J]. Reviews of infectious diseases, 1990, 12 Suppl 7: S849-60. DOI:
10.1093/clinids/12.supplement_7.s849[2] BEAN B. Antiviral therapy: current concepts and practices.[J]. Clinical Microbiology Reviews, 1992, 5 2: 146-182. DOI:
10.1128/cmr.5.2.146[3] R J ASHTON. Antiviral activity of famciclovir and acyclovir in mice infected intraperitoneally with herpes simplex virus type 1 SC16.[J]. Journal of Antimicrobial Chemotherapy, 1994, 34 2: 287-290. DOI:
10.1093/jac/34.2.287
