2-Cyanoethyl 3-oxobutanoate

Chemical Properties

Yellow to brown liquid.

Uses

2-Cyanoethyl Acetoacetate is an intermediate in the synthesis of Felodipine-d3 (F232377), a labelled dihydropyridine calcium channel blocker.

Application

2-Cyanoethyl 3-oxobutanoate is a diazepine that has been shown to have cardiac effects. It is used as a drug substance in the synthesis of diazepinone, which is a nitrosable drug and an infarction agent. It has been shown to induce cardiac contractility by binding to the functional site on the beta-1 adrenergic receptor. This compound also acts as an inhibitor of lipase, which may be due to its similarity in structure to the pharmacophore for this enzyme.