UCL 1684 DITRIFLUOROACETATE HYDRATE

Uses

UCL 1684 ditrifluoroacetate hydrate has been used for analyzing the mechanism for ammonium-mediated displacement of the protonated analyte from analyte-trifluoroacetic acid (TFA) ion-pair. UCL 1684 has also been used as a potassium channel inhibitor to study CNP (C-type natriuretic peptide)-induced relaxations in pig coronary arteries.

Biochem/physiol Actions

UCL 1684 is a potent non-peptide blocker of the apamin-sensitive Ca2+-activated K+?channel. It comprises two quinolinium rings and is similar to apamin?arginine residue. UCL 1684 inhibits calcium-activated K current (Kslow) and modulates islet β-cell.