Description
Noroxymorphone (Item No. 15903) is an analytical reference standard that is structurally categorized as an opioid. It is an active metabolite of oxycodone , noroxycodone (Item Nos.
15902 |
20407), and oxymorphone that can be detected in plasma and urine. Noroxymorphone is also an immediate precursor in the synthesis of several opioids, including naltrexone (Item Nos.
15520 |
ISO60192) and naloxone (Item Nos.
15594 |
ISO60191). Noroxymorphone is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.
References
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10.1124/jpet.103.058602[2] MERJA KOKKI. Maturation of oxycodone pharmacokinetics in neonates and infants: Oxycodone and its metabolites in plasma and urine[J]. British journal of clinical pharmacology, 2016, 83 4: 791-800. DOI:
10.1111/bcp.13164[3] TIMO KORJAMO. Metabolism of oxycodone in human hepatocytes from different age groups and prediction of hepatic plasma clearance.[J]. ACS Applied Energy Materials, 2012: 87. DOI:
10.3389/fphar.2011.00087[4] BOJAN LALOVIC. Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes.[J]. ACS Applied Energy Materials, 2004: 447-454. DOI:
10.1124/dmd.32.4.447[5] DR. BERNHARD GUTMANN. Batch- and Continuous-Flow Aerobic Oxidation of 14-Hydroxy Opioids to 1,3-Oxazolidines—A Concise Synthesis of Noroxymorphone[J]. Chemistry - A European Journal, 2016, 22 30: 10393-10398. DOI:
10.1002/chem.201601902
