Description
ME-3221 is an angiotensin type 1 receptor antagonist potentially for the treatment of hypertension. ME3221 prevents hypertensive complications in aged stroke-prone spontaneously hypertensive rats. n rats and marmosets, ME3221 antagonized angiotensin II-induced pressor responses, but did not affect bradykinin-induced depressor responses. ME3221 lowered the blood pressure in renal hypertensive rats and spontaneously hypertensive rats (SHR), and its ED25 value was 3 times that of losartan.