Uses
Resistomycin is an antibiotic RNA polymerase inhibitor and apoptosis inducer.
Uses
Resistomycin is a tetrahydroxyanthrone that has been independently isolated by several groups and reported to have a broad range of biological activities. Resistomycin is active against bacteria, including mycobacteria, and viruses. Resistomycin induces apoptosis and inhibits RNA polymerase.
Uses
Resistomycin is a tetrahydroxyantrone has been independently isolated by several groups and reported to have a broad range of biological activities. Resistomycin is active against bacteria, including mycobacteria, and viruses. Resistomycin induces apoptosis and inhibits RNA polymerase.
Definition
ChEBI: Resistomycin is a phenanthrol.
Biological Activity
resistomycin is a natural antibiotic.resistomycin is a natural antibiotic produced by several actinobacteriae, such as streptomyces.
in vitro
resistomycin, a tetrahydroxyanthrone derivative, was isolated from the culture broth of streptomyces sulphureus and a similar polyphenolic dianthraquinone, hypericin, was isolated from an extract of hypericum perforatum l. as modulators for apoptosis. in human megakaryoblastic leukemia cmk-7 cells, resistomycin could inhibit apoptosis induced by actinomycin d (ad) with or without acceleration by colcemid (cl), ic50 for inhibition against ad-induced apoptosis was about 0.5 μm and ic50 for inhibition against ad plus cl-induced apoptosis was about 1 μm. cl alone induced weak apoptosis in cells, which could be enhanced by resistomycin. moreover, it was found that both hypericin and resistomycin were able to scavenge superoxide anion radicals at the same rate as luteolin. in addition, pkc in cmk-7 cells could be inhibited by hypericin and luteolin, but not obviously inhibited by resistomycin [1].
References
[1] shiono, y. ,shiono, n.,seo, s., et al. effects of polyphenolic anthrone derivatives, resistomycin and hypercin, on apoptosis in human megakaryoblastic leukemia cmk-7 cell line. z. naturforsch. c. 57(9-10), 923-929 (2002).
