Description
5-Chloro-2-nitrobenzotrifluoride (5-chloro-2-nitrobenzotrifluoride) is an organic compound that is mainly used in the field of organic synthesis, especially in the pharmaceutical industry as an intermediate for the synthesis of certain drugs.
Uses
5-Chloro-2-nitrobenzotrifluoride serves as a reagent for synthesizing 2,6-dimethyl-4-(4-nitro-3-(trifluoromethyl)phenoxy)aniline by reacting with 4-amino-3,5-xylenol[1]. It reacts with hexadecylamine under reflux to produce N-hexadecyl-4-nitro-3-(trifluoromethyl)aniline (Amp-NTA)[2].
References
[1]Bong, S., Yeo, H., Ku, B.-C., Goh, M., & You, N.-H. (2017). Highly soluble polyimide based on asymmetric diamines containing trifluoromethyl group for high performance dielectric material. Macromolecular Research, 26(1), 85–91.
https://doi.org/10.1007/s13233-018-6010-7 [2]Sharma, N., Dhyani, A. K., Marepally, S., & Jose, D. A. (2020). Nanoscale lipid vesicles functionalized with a nitro-aniline derivative for photoinduced nitric oxide (NO) delivery. Nanoscale Advances, 2(1), 463–469.
https://doi.org/10.1039/c9na00532c
