Guanosine 3,5-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt - Calbiochem Chemical Properties,Usage,Production
General Description
A potent, cell-permeable, and metabolically stable inhibitor of protein kinase G (PKG; Ki = 4 μM). Acts as a cyclic nucleotide-gated channel agonist (EC50 = 173.5 μM). Significantly more lipophilic and membrane-permeable than cGMP or Rp-cGMPS. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. Note: 5 μmol = 2.31 mg.
Biochem/physiol Actions
Cell permeable: yes
Preparation Products And Raw materials
Guanosine 3,5-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt - Calbiochem Suppliers
