Description
Resolvin D3-d5 (RVD3-d5 is intended for use as an internal standard for the quantification of RVD3 (Item No. 13834) by GC- or LC-MS. RVD3 is a DHA-derived product first identified in mouse inflammatory exudates.1 It reduces neutrophil infiltration in vivo in both mouse peritonitis and dermal inflammation. In addition to suppressing leukocyte migration, RVD3 enhances macrophage phagocytosis and efferocytosis.2 Unlike other resolvins, RVD3 appears late in resolution in mouse peritonitis.2,3WARNING This product is not for human or veterinary use.
References
[1] CHARLES N SERHAN. Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals.[J]. Journal of Experimental Medicine, 2002, 196 8: 1025-1037. DOI:
10.1084/jem.20020760[2] JESMOND DALLI. Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents.[J]. Chemistry & biology, 2013, 20 2: 188-201. DOI:
10.1016/j.chembiol.2012.11.010[3] SERHAN C N. Pro-resolving lipid mediators are leads for resolution physiology[J]. Nature, 2014, 510 7503: 92-101. DOI:
10.1038/nature13479[4] DAVID MERIWETHER. Apolipoprotein A-I mimetics mitigate intestinal inflammation in COX2-dependent inflammatory bowel disease model.[J]. Journal of Clinical Investigation, 2019, 129 9: 3670-3685. DOI:
10.1172/jci123700
