Description
Calmodulin-dependent protein kinase II (290-309) is a synthetic peptide derived from the rat brain protein sequence that contains the calmodulin binding domain.1,2 It inhibits calcium/calmodulin-dependent protein kinase II (CaMKII) with an IC50 value of 52 nM and CaMKII-dependent phosphodiesterase activity (IC50 = 1.1 nM). Calmodulin-dependent protein kinase II (290-309) has been used in the study of CaM binding, autophosphorylation, and dynamics.3,4WARNING This product is not for human or veterinary use.
References
[1] HUDMON A, SCHULMAN H. Calcium | Calcium/Calmodulin-Dependent Protein Kinase II[J]. Encyclopedia of Biological Chemistry III, 1900, C-19 1: 0. DOI:
10.1016/b978-0-12-819460-7.00099-2[2] C R LIN. Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1987, 84 16: 5962-5966. DOI:
10.1073/pnas.84.16.5962[3] THOMAS WYTTENBACH. The Effect of Calcium Ions and Peptide Ligands on the Relative Stabilities of the Calmodulin Dumbbell and Compact Structures[J]. The Journal of Physical Chemistry B, 2009, 114 1: 437-447. DOI:
10.1021/jp906242m[4] R J COLBRAN T R S. Calcium/calmodulin-independent autophosphorylation sites of calcium/calmodulin-dependent protein kinase II. Studies on the effect of phosphorylation of threonine 305/306 and serine 314 on calmodulin binding using synthetic peptides.[J]. The Journal of Biological Chemistry, 1990, 265 19: 11213-11219.
