[Des-His1,Glu9]-Glucagon (1-29) amide (trifluoroacetate salt)

Description

[Des-His1,Glu9]-Glucagon (1-29) amide is a peptide glucagon receptor antagonist (pA2 = 7.25 for glucagon binding to isolated rat liver membranes).1 It binds to glucagon receptors in a magnesium- and GTP-independent manner to stimulate breakdown of inositol phospholipids by phospholipase C, but has no effect on adenylate cyclase activity, in hepatocytes.1,2 In vivo, [Des-His1,Glu9]-glucagon (1-29) amide prevents glucagon-induced hyperglycemia in rabbits and decreases blood glucose in rats with diabetes induced by streptozotocin (Item No. 13104).1WARNING This product is not for human or veterinary use.

References

[1] CECILIA G. UNSON  R. B M  Ellen M Gurzenda. Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist[J]. Peptides, 1989, 10 6: Pages 1171-1177. DOI: 10.1016/0196-9781(89)90010-7
[2] S R POST  H S T  P G Rubinstein. Mechanism of action of des-His1-[Glu9]glucagon amide, a peptide antagonist of the glucagon receptor system.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1993, 90 5: 1662-1666. DOI: 10.1073/pnas.90.5.1662