Chemical Properties
white to very slightly yellow crystalline powder
Uses
5-Chlorosalicyaldehyde is a useful synthetic intermediate and a key precursor to a variety chelating agents.5-Chlorosalicyaldehyde is used to synthesize imine resveratrol (R150000) derivatives as multi-targeted agents against Alzheimer's disease.
Synthesis Reference(s)
Synthetic Communications, 20, p. 609, 1990
DOI: 10.1080/00397919008244911Tetrahedron Letters, 15, p. 3463, 1974
Purification Methods
Steam distil it, then crystallise it from aqueous EtOH or *C6H6 (m 100o). It forms complexes with Cu2+ and Fe2+ . [Beilstein 8 H 53, 8 II 45, 8 III 181, 8 IV 224.]
