Uses
Splenopentin diacetate is a synthetic immunomodulating pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin. Splenopentin diacetate influences both early T and B cell differentiation, to increase the number of antibody-forming cells in mice after gamma irradiation[1][2].
Biological Activity
Splenopentin diacetate is a synthetic immunomodulatory pentapeptide corresponding to residues 32-36 of the spleen hormone spleen protein. It affects early T and B cell differentiation, thereby increasing the number of antibody-forming cells in gamma-irradiated mice.
References
[1] Singh VK, et, al. Thymopentin and splenopentin as immunomodulators. Current status. Immunol Res. 1998;17(3):345-68. DOI:
10.1007/BF02786456[2] Rastogi A, et, al. Augmentation of human natural killer cells by splenopentin analogs. FEBS Lett. 1993 Feb 8;317(1-2):93-5. DOI:
10.1016/0014-5793(93)81498-o[3] Audhya T, et, al. Contrasting biological activities of thymopoietin and splenin, two closely related polypeptide products of thymus and spleen. Proc Natl Acad Sci U S A. 1984 May;81(9):2847-9. DOI:
10.1073/pnas.81.9.2847[4] Gruner S, et, al. Stimulation of the recruitment of epidermal Langerhans cells by splenopentin. Arch Dermatol Res. 1990;281(8):526-9. DOI:
10.1007/BF00412738
