Uses
9-HETE, a monohydroxy fatty acid, is the lipoxygenase metabolite of arachidonic acid (HY-109590)[1].
Definition
ChEBI: 9-HETE is an HETE that is (5Z,7E,11Z,14Z)-icosa-5,7,11,14-tetraenoic acid in which the hydroxy group is located at position 9. It has a role as a metabolite. It is a conjugate acid of a 9-HETE(1-).
References
[1] Goetzl EJ, et al. Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils. J Exp Med. 1979 Aug 1;150(2):406-11. DOI:
10.1084/jem.150.2.406[2] WILLIAM S. POWELL Joshua R. Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid[J]. Biochimica et biophysica acta. Molecular and cell biology of lipids, 2015, 1851 4: Pages 340-355. DOI:
10.1016/j.bbalip.2014.10.008[3] JORGE CAPDEVILA . Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450[J]. Biochemical and biophysical research communications, 1986, 141 3: Pages 1007-1011. DOI:
10.1016/s0006-291x(86)80144-9[4] MEHDI H. SHISHEHBOR . Systemic elevations of free radical oxidation products of arachidonic acid are associated with angiographic evidence of coronary artery disease[J]. Free Radical Biology and Medicine, 2006, 41 11: Pages 1678-1683. DOI:
10.1016/j.freeradbiomed.2006.09.001[5] ZONGYUAN WU, FANG WEI* Analytical Strategy for Oxylipin Annotation by Combining Chemical Derivatization-Based Retention Index Algorithm and Feature Tandem Mass Spectrometric Fragmentation as a Biomarker Discovery Tool[J]. Analytical Chemistry, 2023, 95 43: 15933-15942. DOI:
10.1021/acs.analchem.3c02789[6] YILIN PANG . LC−MS/MS-based arachidonic acid metabolomics in acute spinal cord injury reveals the upregulation of 5-LOX and COX-2 products[J]. Free Radical Biology and Medicine, 2022, 193: Pages 363-372. DOI:
10.1016/j.freeradbiomed.2022.10.303
