Uses
Cardiolipin sodium salt from bovine heart has been used:
- as a phospholipid standard in thin layer chromatography for the quantification of total mitochondrial lipids of Neurospora crassa(89)
- as an internal standard in reverse phase high performance liquid chromatography (RP-HPLC) for quantification of bacterial lipid extracts(90)
- as an antigen to evaluate IgM reaction in systemic lupus erythematosus (SLE) patients(91)
General Description
Cardiolipin is localized in the inner membrane of mitochondria. It contains 18 carbon atoms, 3-phosphatidyl groups connected via a glycerol bridge. Cardiolipin is an important component of ATP synthase enzyme.
Biochem/physiol Actions
Cardiolipin is a mitochondrial phospholipid that is found in mammalian tissues in low concentrations. It is often a membrane component. Inhibits cell attachment of fibronectin, vitronectin and Type I collagen.
