Description
MitoLite™ reagents are fluorogenic probes that can be used to label mitochondria within live cells. They are hydrophobic and easily cross live cell membranes to accumulate in mitochondria likely via the mitochondrial membrane potential gradient. MitoLite™ reagents contain a cell-retaining group, which allows them to remain in the mitochondria long-term, and their fluorescence can be measured using fluorescence microscopy, microplate fluorometry, or flow cytometry. MitoLite™ Blue FX490 has been used to assess mitochondrial localization in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells.1 MitoLite™ Blue FX490 displays excitation/emission maxima of 350/490 nm, respectively, and can be used for live and fixed cell applications.WARNING This product is not for human or veterinary use.
References
[1] ZBYNEK HEGER . Co-delivery of VP-16 and Bcl-2-targeted antisense on PEG-grafted oMWCNTs for synergistic in vitro anti-cancer effects in non-small and small cell lung cancer[J]. Colloids and Surfaces B: Biointerfaces, 2017, 150: Pages 131-140. DOI:
10.1016/j.colsurfb.2016.11.023
