N-(Aminooxy-PEG3)-N-bis(PEG4-t-butyl ester)

Description

N-(Aminooxy-PEG3)-N-bis(PEG4-t-butyl ester) is a branched aminooxy linker. It can react with aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The t-butyl ester group can be hydrolyzed under acidic conditions. The hydrophilic PEG linkers increase the water solubility of the compound. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.

Uses

N-(Aminooxy-PEG3)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005