2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane

Description

2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane enable PEGylation via Click Chemistry. The terminal carboxylic acids can react with primary amino(NH2) groups in the presence of activator HATU or EDC.

Uses

2-Azido-PEG3-amido-13-biscarboxylethoxypropane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005