Propargyl-PEG4-Tos
- Product NamePropargyl-PEG4-Tos
- CAS875770-32-4
- CBNumberCB53062628
- MFC18H26O7S
- MW386.46
- MDL NumberMFCD28950765
- MOL File875770-32-4.mol
Chemical Properties
| Boiling point | 498.1±45.0 °C(Predicted) |
| Density | 1.177±0.06 g/cm3(Predicted) |
| form | Liquid |
| color | Colorless to light yellow |
Propargyl-PEG4-Tos Price
| Product number | Packaging | Price | Product description | Buy |
|---|---|---|---|---|
| Synthonix P8651 | 50mg | $180 | Propargyl-PEG5-Tos 95% |
Buy |
| Synthonix P8651 | 100mg | $280 | Propargyl-PEG5-Tos 95% |
Buy |
| Synthonix P8651 | 250mg | $380 | Propargyl-PEG5-Tos 95% |
Buy |
| BroadPharm BP-22781 | 250mg | $450 | Propargyl-PEG5-Tos 98% |
Buy |
| Synthonix P8651 | 500mg | $580 | Propargyl-PEG5-Tos 95% |
Buy |
Propargyl-PEG4-Tos Chemical Properties,Usage,Production
Description
Propargyl-PEG5-Tos is a PEG linker containing a tosyl group and a propargyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.Biological Activity
Propargyl-PEG4-Tos is a PROTAC linker belonging to the PEG class and can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs).in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| PEGs
| Cleavable
|
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39894 | 58 | |
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marketing@targetmol.com | United States | 32118 | 58 | |
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sales@huarongpharm.com | CHINA | 3148 | 58 | |
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| +undefined18143011203 | info@chemextension.com | China | 42056 | 58 | |
| +86-15680926068 +86-15680926068 |
1924344760@confluore.cn | China | 2995 | 58 | |
| +8615303909093 | sales@compound-net.com | China | 2914 | 58 | |
| 021-50460086-9 15921403865 |
han_yajun@dctc.daicel.com | China | 7189 | 65 | |
| 400-164-7117 13681763483 |
product02@bidepharm.com | China | 41462 | 60 |
View Lastest Price from Propargyl-PEG4-Tos manufacturers
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