General Description
General control of amino acid synthesis protein 5-like2 (GCN5L2) also known as KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM]GCN5L2 gene is located on human chromosome 17q21.2. This protein is expressed in ovaries.
Biochem/physiol Actions
General control of amino acid synthesis protein 5-like2 (GCN5L2) regulates periodontitis through acetylation of dickkopf-related protein 1 (DKK1). It regulates early region 1A (E1A) dependant transactivation of human adenovirus. The protein modulates osteogenic differentiation of mesenchymal stem cells by blocking NF-κB (nuclear factor-κB) signalling pathway. GCN5 interacts with (origin recognition complex subunit 5) Orc5?and improves the chromatin-opening function of Orc5.
