Regorafenib (Hydrochloride)
- Product NameRegorafenib (Hydrochloride)
- CAS835621-07-3
- CBNumberCB52624290
- MFC21H16Cl2F4N4O3
- MW519.2763528
- EINECS692-722-3
- MDL NumberMFCD22417053
- MOL File835621-07-3.mol
- MSDS FileSDS
Chemical Properties
storage temp. | Store at -20°C |
solubility | ≥ 25.95 mg/mL in DMSO, ≥ 8.75 mg/mL in EtOH with ultrasonic and warming |
form | Powder |
Regorafenib (Hydrochloride) Price
Product number | Packaging | Price | Product description | Buy |
---|---|---|---|---|
ChemScene CS-0725 | 50mg | $50 | Regorafenib(Hydrochloride) 99.58% |
Buy |
ApexBio Technology A3750 | 10mg | $65 | Regorafenibhydrochloride |
Buy |
ChemScene CS-0725 | 100mg | $80 | Regorafenib(Hydrochloride) 99.58% |
Buy |
American Custom Chemicals Corporation KIN0001550 | 5MG | $154 | REGORAFENIB HYDROCHLORIDE 95.00% |
Buy |
AK Scientific 4001AH | 5mg | $186 | Regorafenibhydrochloride |
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Regorafenib (Hydrochloride) Chemical Properties,Usage,Production
Uses
BAY 73-4506 (Regorafenib) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf.in vitro
Regorafenib potently inhibits VEGFR2 autophosphorylation in NIH-3T3/VEGFR2 cells with an IC50 of 3 nM. In HAoSMCs, regorafenib inhibits PDGFR-β autophosphorylation after stimulation with PDGF-BB, with an IC50 of 90 nM. Regorafenib inhibits the proliferation of VEGF165-stimulated HUVECs, with an IC50 of 3 nMf. Regorafenib causes a concentration-dependent decrease in Hep3B cell growth, having an IC50 of 5 μM. Regorafenib subsequently increases the levels of phospho-c-Jun, a JNK target, but not total c-Jun in Hep3B cells.in vivo
Regorafenib effectively inhibits growth of the Colo-205 xenografts in the dose range of 10-100 mg/kg reaching a TGI of 75% at day 14 at the 10 mg/kg dose. In the MDA-MB-231 model, regorafenib is highly efficacious at a dose as low as 3 mg/kg, resulting in a significant TGI of 81%, which increases to 93% at doses of 10 and 30 mg/kg, where tumor stasis is reached.References
[1] Phan, Chiuyen et al. “Isomorphous Crystals Formed by the Similar Supramolecular Motifs in Sorafenib Hydrochloride and Regorafenib Hydrochloride Salts.” 2019. 0.Preparation Products And Raw materials
Raw materials
Regorafenib (Hydrochloride) Supplier
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Regorafenib (Hydrochloride) Spectrum
835621-07-3, Regorafenib (Hydrochloride)Related Search
- 4-(4-(3-(4-chloro-3-(trifluoroMethyl)phenyl)ureido)-3-fluorophenoxy)-2-(MethylcarbaMoyl)pyridine 1-oxide
- (S,S')-3-METHYL-1-(2-PIPERIDINOPHENYL)BUTYLAMINE, N-ACETYL-GLUTAMATE SALT
- 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide hydrate
- Regorafenib
- Bortezomib
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