Uses
Anti-CXCR4 antibody produced in rabbit is suitable for immunohistochemistry of formalin-fixed, paraffin-embedded tissue sections at a working concentration of 9-14 μg/mL. It was used to stain rat bladder sections at a dilution of 1:2000, incubated overnight.
Biochem/physiol Actions
CXCR4 is a cell surface receptor of the chemokine CXCL12 (SDF-1) and is involved in metastasis, hematopoiesis and immune responses. It acts with CD4 to facilitate the entry of HIV into target cells. CXCR4 has important roles in tumor initiation, proliferation, invasion and metastasis of breast cancer cells.
