Description
TTA-P2 (918430-49-6) is a potent (IC50 = 100 nM), specific, and reversible antagonist of T-type calcium channels with no activity at high voltage calcium channels.1,2 Highly potent in two animal models of pain in vivo.3
References
Shipe et al. (2008), Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist; J. Med. Chem., 51 3692
Dreyfus et al. (2010), Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of I(T)window; J. Neurosci., 30 99
Choe et al. (2011), TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent; Mol. Pharmacol., 80 900