Description
During unfavorable environmental conditions,
C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival. DAF-
12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in
C. elegans. DAF-
12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. Δ
4-
Dafachronic acid is a racemic version of a sterol-
derived hormone that acts as a ligand of DAF-
12. Δ
4-
Dafachronic acid binds to and transactivates DAF-
12, rescuing hormone deficiency in transgenic dauer larvae and promoting reproductive maturation into adults. The (25S) diastereomer of Δ
4-
dafachronic acid is significantly more potent than its (25R) counterpart (EC
50s = 23 and 66 nM, respectively).
Definition
ChEBI: Delta(4)-dafachronic acid is a cholestanoid that is cholest-4-en-26-oic acid which is substituted at position 3 by an oxo group. It is a 3-oxo-Delta(4) steroid, a member of dafachronic acids and a C27-steroid. It is a conjugate acid of a Delta(4)-dafachronate.
