Chemical Properties
Colorless to light yellow liqui
Uses
(
R)-(+)-Glycidol may be used in the following synthesis:
- heteroarylpropane-2,3-diols, useful for combinatorial oligomer synthesis
- enantiomerically pure (2S,3S)- and (2S,3R)-threoninol and -hydroxyphenylalaninol
- 2-amino-1,4-anhydro-pentitol and 3-amino-1,5-anhydro-4-deoxy-hexitol with the arabino configuration
- (S)-4-tosyloxymethyl-2-oxazolidinone, required for the synthesis of protected amino alcohol derivatives
- 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine [(S)-HPMPC]
- chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product
Uses
(R)-(+)-Glycidol can be used to construct chiral building blocks of epoxyvinyl iodide intermediates in the synthesis of furanocembrane, a marine natural product.
Definition
ChEBI: (R)-glycidol is a glycidol. It is functionally related to a (R)-1,2-epoxypropane. It is an enantiomer of a (S)-glycidol.
General Description
Enantioselective esterification of (
R)-(+)-glycidol with
n-butyric acid in organic media using hybrid gel-entrapped lipase on Celite has been reported.
Purification Methods
[S(-)-isomer, § also available on polymer support, has b 49-50o/7mm, 66-67o/19mm, [ ] D -1 5o(neat)], [R(+)-isomer has b 56 -5 6 . 5o/11mm, d 4 1.117, n D 1.429, [ ] D +15o (neat)]. Purify glycidol by fractional distillation.
