ANTI-CATHEPSIN L

General Description

Cathepsin L is a cysteine protease and is secreted by numerous transformed cells in its inactive pre-form. It is ubiquitously expressed and is localized in nucleus. Cathepsin L have substrate interacting region located in L and R domain loops.

Biochem/physiol Actions

Cathepsin L expression is correlated with the metastatic potential of transformed cells. Cathepsin L is capable of degrading protein constituents of the extracellular matrix, this enzyme is thought to play a crucial role in tumor progression, metastasis and other disorders where the destruction of the matrix is the major cause of disease.