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7-Dehydrocholesterol

7-Dehydrocholesterol Structure
7-Dehydrocholesterol
  • CAS No.434-16-2
  • Chemical Name:7-Dehydrocholesterol
  • CBNumber:CB5165113
  • Molecular Formula:C27H44O
  • Formula Weight:384.64
  • MOL File:434-16-2.mol
7-Dehydrocholesterol Property
Safety
  • Safety Statements  :24/25
  • WGK Germany  :3
  • RTECS  :FZ5650000
  • F  :8-10-23
  • HS Code  :29061990
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
7-Dehydrocholesterol Price More Price(33)
  • Brand: Sigma-Aldrich
  • Product number: 30800
  • Product name : 7-Dehydrocholesterol
  • Purity: ≥95.0% (HPLC)
  • Packaging: 5 g
  • Price: $56.1
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 30800
  • Product name : 7-Dehydrocholesterol
  • Purity: ≥95.0% (HPLC)
  • Packaging: 5g-f
  • Price: $54.2
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 14612
  • Product name : 7-dehydro Cholesterol
  • Purity: ≥90%
  • Packaging: 10g
  • Price: $55
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 14612
  • Product name : 7-dehydro Cholesterol
  • Purity: ≥90%
  • Packaging: 5g
  • Price: $29
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: TRC
  • Product number: D229455
  • Product name : (3β)-7-DehydroCholesterol
  • Purity: 
  • Packaging: 25g
  • Price: $135
  • Updated: 2021/12/16
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7-Dehydrocholesterol Chemical Properties,Usage,Production

  • Description 7-dehydro Cholesterol (7-DHC) is an immediate precursor of cholesterol. It is reduced to cholesterol by the enzyme 3β-hydroxysterol-Δ7-reductase (DHCR7) in the last step of cholesterol biosynthesis. 7-DHC accumulates in Smith-Lemli-Opitz syndrome (SLOS), a disorder characterized by a mutation in the DHCR7 gene and decreased cholesterol levels in bodily tissues and fluids, as well as microcephaly, intellectual disability, and distinctive dysmorphic features. It is highly susceptible to free radical oxidation, giving rise to several oxysterols that may be involved in the pathogenesis of SLOS. 7-DHC levels are increased in brain, liver, and serum in a rat model of SLOS induced by the DHCR7 inhibitor AY 9944 (Item No. 14611). 7-DHC is a provitamin that is converted to vitamin D3 (Item No. 11792) by ultraviolet-B (UVB) light in a human skin equivalent system and in isolated human skin samples.
  • Chemical Properties white to off-white fine crystalline powder
  • Uses A vitamin precursor.
    Vitamin D3 is produced by the action of sunlight or ultraviolet irradiation from the precursor, 7-dehydrocholesterol (7-DC), that is synthesized in the skin of animals and humans.
    In most tissues of the body, 7-dehydrocholesterol is the immediate precursor of cholesterol. It is reduced to cholesterol by the enzyme 3β-hydroxysterol-Δ7-reductase (DHCR7) in the last step of cholesterol biosynthesis. 7-DHC accumulates in Smith-Lemli-Opitz syndrome (SLOS), a disorder characterized by a mutation in the DHCR7 gene and decreased cholesterol levels in bodily tissues and fluids, as well as microcephaly, intellectual disability, and distinctive dysmorphic features. It is highly susceptible to free radical oxidation, giving rise to several oxysterols that may be involved in the pathogenesis of SLOS. 7-DHC levels are increased in brain, liver, and serum in a rat model of SLOS induced by the DHCR7 inhibitor AY 9944. 7-DHC is a provitamin that is converted to vitamin D3 by ultraviolet-B (UVB) light in a human skin equivalent system and in isolated human skin samples.
  • Uses 7-Dehydrocholesterol (7-DHC), a 5,7-conjugated diene sterol is a biosynthetic precursor of cholesterol. It helps in the production of vitamin D3 when exposed to ultraviolet B (UVB) radiation. 7-Dehydrocholesterol has been used as an internal standard to determine sterols.
    7-dehydrocholesterol is used in the diagnosis of Smith-Lemli-Opitz syndrome. Blood and tissue of infants with Smith- Lemli-Opitz (SLO) syndrome contain reduced amounts of cholesterol and greatly increased concentrations of 7-dehydrocholesterol and of its isomer 8-dehydrocholesterol.
  • Uses A vitamin D3 precursor.
7-Dehydrocholesterol Preparation Products And Raw materials
Raw materials
Preparation Products
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434-16-2, 7-DehydrocholesterolRelated Search:
  • (3)-7-Dehydrochlesterol
  • (3beta)-Cholesta-5,7-dien-3-ol
  • (3-beta)-cholesta-7-dien-3-ol
  • (3beta)-cholesta-7-dien-3-ol
  • 3-Hydroxycholesta-5,7-diene
  • cholesta-5,7-dien-3-beta-ol
  • Cholesta-5,7-dien-3-ol
  • Cholesta-5,7-dien-3-ol, (3beta)-
  • Cholesterol, 7-dehydro-
  • Dehydrocholesterin
  • Dehydrocholesterol
  • delta(sup5,7)-cholesterol
  • delta(sup7)-cholesterol
  • DELTA5,7-Cholestadien-3beta-ol
  • delta5,7-Cholesterol
  • 5,7-Cholestandien-3.beta.-ol
  • 5,7-Cholestandien-3beta-ol
  • 7,8-Didehydrocholesterol
  • 7-Dehydrocholesterin
  • 7-dehydro-cholestero
  • 7-dien-3-ol,(3.beta.)-Cholesta-5
  • 7-Dehydrochlesterol
  • Provitamin D<sub>3</sub>
  • 7-Dehydrocholesterol, contains ca. 1 mole of methanol of crystallization, 97.50%
  • 10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol
  • 7-DEHYDROCHOLESTEROL (7-DHC)
  • (-)-7-Dehydrocholesterol, 3β-Hydroxy-5,7-cholestadiene, 5,7-Cholestadien-3β-ol, Provitamin D3
  • 3beta-Hydroxycholesta-5,7-diene
  • 7-Dehydrocholesterol, 97.5%, contains ca. 1 mole of methanol of crystallization
  • 7-Dehydrocholesterol, contains ca. 1 mole of methanol of crystallization
  • Δ5,7-Cholesterol
  • Δ7-Cholesterol
  • 7-DehydrocholesterolProvitamine
  • 7-Dehydrocholseterol
  • 7-Dehydrocholesterolmonohydrate,97%
  • (3b)-7-Dehydrocholesterol
  • 7-Dehydrocholesterol, contains ca. 1 mole of methanol of crystallization, 97.5%
  • (3β)-7-Dehydro Cholesterol
  • 7-Dehydrocholesterol, contains ca. 1 Mole of Methanol of crystallization, 97.5% 5GR
  • 7-DHC
  • IMp. B (EP): Cholesta-5,7-dien-3β-ol(7,8-Didehydrocholesterol
  • 7-Dehydrocholesterol (Provitamin D3)
  • DEHYDROCHOLESTEROL, 7-(AS)
  • 7-Dehydrocholesterol (ProvitaMin D)
  • (3-beta)-7-Dehydrocholesterol (Cholesta-5,7-dien-3-beta-ol)
  • 7-Dehydrocholesterol - min95%
  • Cholecalciferol Impurity 2(Cholecalciferol EP Impurity B)
  • 3-beta-7-Dehydro Cholesterol
  • Cholecalciferol EP Impurity B
  • delta7-Cholesterol
  • Provitamin D(sub 3)
  • provitamind(sub3)
  • DEHYDROCHOLESTEROL, 7-
  • (-)-7-DEHYDROCHOLESTEROL
  • 7-DEHYDROCHOLESTEROL
  • 7-DEHYDROCHOLESTEROL MONOHYDRATE
  • 5,7-CHOLESTADIEN-3-BETA-OL MONOHYDRATE
  • 5,7-CHOLESTADIEN-3BETA-OL