Fluorescein isothiocyanate-inulin

Uses

• Development and validation of bioengineered intestinal tubules for translational research aimed at safety and efficacy testing of drugs and nutrients.: This study employs Inulin–FITC to investigate the absorption characteristics of bioengineered intestinal models, providing critical data on gut permeability and nutrient interaction, which is crucial for pharmaceutical and nutritional research (Jochems et al., 2019).


• Role of Vitamin D in Maintaining Renal Epithelial Barrier Function in Uremic Conditions.: Utilizes Inulin–FITC to measure the efficacy of Vitamin D in preserving renal barrier function under stress conditions, which could lead to new treatments for chronic kidney disease (Mihajlovic et al., 2017).


• Inhibition of p38 mitogen-activated protein kinase attenuates butyrate-induced intestinal barrier impairment in a Caco-2 cell monolayer model.: This investigation highlights the role of Inulin–FITC in studying the protective effects of kinase inhibition on intestinal barriers, relevant for gastrointestinal disorder treatments (Huang et al., 2014).


• Measurement of glomerular filtration rate in conscious mice using FITC-inulin clearance.: Demonstrates the utility of Inulin–FITC in precise, non-invasive measurements of renal function, essential for nephrology research and therapy development (Qi and Breyer, 2009).


• PPAR gamma agonist normalizes glomerular filtration rate, tissue levels of homocysteine, and attenuates endothelial-myocyte uncoupling in alloxan induced diabetic mice.: Incorporates Inulin–FITC to assess the efficacy of a PPAR gamma agonist in diabetic nephropathy, providing insights into metabolic disease management (Rodriguez et al., 2008).