DMP 777

Product NameDMP 777
CAS157341-41-8
CBNumberCB51333719
MFC31H40N4O6
MW564.67
MDL NumberMFCD00871548
MOL File157341-41-8.mol
MSDS FileSDS

Chemical Properties

Density	1.227
storage temp.	Store at -20°C
solubility	DMSO : 38.33 mg/mL (67.88 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form	Powder
pka	pKa 7.04(H2O tundened Iundened) (Uncertain)
color	White to yellow
FDA UNII	3Q0469283P

DMP 777 Price

Product number	Packaging	Price	Product description	Buy
ChemScene CS-0355	5mg	$217	DMP 777 99.82%	Buy
ChemScene CS-0355	10mg	$325	DMP 777 99.82%	Buy
ChemScene CS-0355	25mg	$552	DMP 777 99.82%	Buy
ChemScene CS-0355	50mg	$883	DMP 777 99.82%	Buy
ChemScene CS-0355	100mg	$1462	DMP 777 99.82%	Buy

DMP 777 Chemical Properties,Usage,Production

Uses

DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.

Biological Activity

DMP 777 is a potent, selective, orally available inhibitor of human leukocyte elastase (HLE).

in vivo

DMP-777-treated rats show a marked decrease in H/K-ATPase staining parietal cells. DMP-777-induced loss of parietal cells is significantly ameliorated with coadministration of omeprazole. DMP-777-treated animals demonstrates marked foveolar hyperplasia in the fundus with prominent expansion of diastase-resistant, PAS-positive surface mucous cells. When DMP-777 is coadministered with omprazole, there is a significant decrease in BrdUpositive S-phase cells compared with rats that receive DMP-777 alone. After oral dosing of monkeys at 40 mg/kg with DMP-777 the only stereoisomer detected in the post-dose plasma samples is the starting material DMP-777, and no inversion of the configuration at positions 'a' and 'b' of DMP- 777 has occurred in vivo. Mist1-/- mice treated with DMP-777 show fewer chief cell to SPEM transitions. Mist1-/- mice treated with L635 demonstrates significantly fewer proliferative SPEM cells compared to control mice.

target

Human leukocyte elastase (HLE)

References

[1] Ogawa M, et al. Omeprazole treatment ameliorates oxyntic atrophy induced by DMP-777. Dig Dis Sci. 2006 Mar;51(3):431-9. DOI:10.1007/s10620-006-3151-x
[2] Zagrobelny J, et al. Separation of the four stereoisomers of a potent inhibitor (L-694,458) of human leukocyte elastase and its determination in human plasma using achiral/chiral chromatography with column switching. J Pharm Biomed Anal. 1998 Sep 1;17(6-7 DOI:10.1016/s0731-7085(98)00071-5
[3] Weis VG, et al. Maturity and age influence chief cell ability to transdifferentiate into metaplasia. Am J Physiol Gastrointest Liver Physiol. 2016 Nov 23:ajpgi.00326.2016 DOI:10.1152/ajpgi.00326.2016

Preparation Products And Raw materials

DMP 777 Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
Shanghai Holy Biohemdeviser Co., Ltd	021-61551100		China	443	57
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7545	61
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4853	58
SPIRO PHARMA		eric_feng1954@126.com	China	9239	55
BOC Sciences	16314854226	info@bocsci.com	United States	9909	65
Guangzhou QiYun Biotechnology Co., Ltd.	020-61288194 61288195	505721671@qq.com	China	3853	58
Shanghai YuanYe Biotechnology Co., Ltd.	18916372613	yanzihan@shyuanye.com	China	87240	60
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	8000	62
Musechem	+1-800-259-7612	info@musechem.com	United States	4648	60

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