Description
(±)-
Talinolol is a β
1-
selective adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity. By blocking β
1-
adrenergic receptors, talinolol delays the conduction of stimuli in the AV node, reduces the sino-
atrial conduction time, and impedes the sinus node automaticity. Because its metabolism in human liver microsomes is well understood, (±)-
talinolol is useful for examining the activity of the drug-
transporting MDR1 gene product P-
glycoprotein.
Chemical Properties
Off-White to Pale Pink Solid
Uses
Selective β1-adrenergic blocker structurally related to Practolol. Antihypertensive; antiarrhythmic.
Definition
ChEBI: Talinolol is a member of ureas.
References
[1] abmann i. the actions of talinolol, a β1-selective beta blocker, in cardiac arrhythmia and acute myocardial infarction[j]. current medical research and opinion, 2008, 13(6): 325-342.
[2] trausch b, oertel r, richter k, et al. disposition and bioavailability of the β1‐adrenoceptor antagonist talinolol in man[j]. biopharmaceutics & drug disposition, 1995, 16(5): 403-414.
