[1-(trimethylsilyl)vinyl]magnesium bromide, Fandachem

Uses

1-(Trimethylsilyl)vinylmagnesium Bromide–Copper(I) Iodide reacts with epoxides to give homoallylic alcohols useful for the synthesis of α-methylenebutyrolactones; can function as a synthon for epoxides; adds to D-glyceraldehyde acetonide to give epoxy alcohols and D-threose derivatives. It takes part in the reactions of α-Methylenebutyrolactone Synthesis, Addition to D-Glyceraldehyde Acetonide: Preparation of Epoxy Alcohols and D-Threose Derivatives, etc.

Preparation

1-(Trimethylsilyl)vinylmagnesium Bromide-Copper(I) Iodide is prepared in situ under anhydrous conditions by reacting 1-(trimethylsilyl)vinylmagnesium bromide (1) with Copper(I) Iodide (2) in various molar ratios.